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中国胰腺癌治疗网化疗放疗方法吉西他滨单药化疗联合局部射频透热治疗晚期胰腺癌

吉西他滨单药化疗联合局部射频透热治疗晚期胰腺癌

疗法提供:南通瑞慈医院 袁振茂

治疗方法:

患者给予吉西他滨1 g/m2第1、8、15天化疗,每次吉西他滨入药后30分钟及第3天针对胰腺癌局部行射频热疗,热疗采用RS-1000 热疗仪,热场中心温度控制在42 ℃~43 ℃,持续70分钟,2个周期。

胰腺癌为恶性的消化道肿瘤,发生隐匿,大多数确诊时即处于晚期,手术切除率仅为10%~20%。且对放化疗不敏感,治疗棘手。我院采用新型化疗药吉西他滨联合射频透热治疗晚期胰腺癌得到较好疗效。

(1)吉西他滨是化疗新药,对胰腺癌效果较确切,有效率25%。

(2)射频热疗使靶区温度平稳升至42 ℃~43 ℃并维持1~2 小时,通过破坏小血管结构和功能,影响癌细胞DNA的合成和修复,抑制细胞蛋白的合成与功能,改变细胞膜的结构和通透性,改变细胞内pH值,诱导细胞凋亡等机制促进细胞死亡,癌细胞因分化发育不良,对热耐受远低于正常细胞,肿瘤细胞致死温度为42.5 ℃~43 ℃,正常细胞为45 ℃。

(3)热疗对化疗尚有协同和增敏作用,热疗对化疗的增敏可能通过增加靶区血流量、细胞膜通透性、改变细胞内pH值及改变药物的细胞毒作用、抑制抗癌药物引起的癌细胞损伤的修复并减少或防止耐药性的发生等途径实现。

应用吉西他滨化疗结合射频热疗治疗晚期胰腺癌得到63.2%的有效率,且不良反应轻微。吉西他滨全身化疗联合胰腺局部射频热疗治疗胰腺癌效果好,不良反应小。


 

     
上一条疗法:经动脉持续灌注化疗治疗中晚期胰腺癌
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胰岛素冷藏盒-居家和外出必备
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上海就医 专家指南
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